Theodore Naval Ammunition Magazine was first occupied by the Army in 1942. During WWII and the Korean Conflict, the Army and Navy used the facility for receiving, storing, and shipping ammunition. The site was deactivated in 1964. An incident occurred during a rail shipment from Theodore Naval Ammunition Magazine to PBA. A leaking bomb was discovered during a routine inspection of a rail car at Ponola, Alabama. The bomb was unloaded and the rail car returned to Theodore, Alabama. Although the disposition of the bomb is unknown, there is no evidence of a burial site within the boundary of the Theodore Naval Ammunition Magazine.

Theodore Naval Ammunition Magazine is where the Navy unloaded the SS Francis L. Lee, which transported German toxic-filled munitions after World War II (WWII). By the time it reached Theodore, the cargo had severely deteriorated. Dunnage was shattered and munitions were leaking. Because of these circumstances, the Guard and Security Unit [now known as the Technical Escort Unit (TEU)] from Edgewood, Maryland, unloaded and stored the shipment, pending rail transport to the Gulf Chemical Warfare Depot at Huntsville, Alabama, the Eastern Depot at Edgewood, Maryland, and the Midwest Depot at Pine Bluff Arsenal (PBA), Arkansas.

The site was identified as a suspect recovered chemical warfare materiel (RCWM) site where DoD has determined that "No Further Action is Warranted".

USACE completed a preliminary assessment of this site in January 1988 and concluded there was no evidence of any ordnance remaining onsite. At the time, however, the investigators were unaware of the information recently found from the historical survey. In August 1993, during preparation of the Archive Search Report, a site survey of the Theodore Naval Ammunition Magazine was made. No evidence of CWM was found.